Upregulation of miR-29a in vivo can attenuate the cardiac hypertrophy response induced by isoproterenol hydrochloride via targeting the nuclear receptor peroxisome proliferator-activated receptor δ (PPARD) and downregulating atrial natriuretic factor, suggesting that miR-29a can protect the myocardium in cardiac hypertrophy (100). The gene discussed is NPPA; the disease is cardiac hypertrophy.