Another cardiac fibroblast-derived exosomal protein (such as miRNA-132) is miRNA-21_3p (miRNA-21*), a “star” pro-fibrotic and pro-hypertrophic miRNA that induces cardiac hypertrophy via its targets of SORBS2 (sarcoplasmic protein sorbin and SH3 domain-containing protein2) and PDLIM5 (PDZ and LIM domain 5) (95, 96, 101). This evidence concerns the gene PDLIM5 and cardiac hypertrophy.