This study shows that cardiac structure (i.e., LVMi and LAVi) and diastolic function (i.e., E/e′) of patients with RA were associated with circulating biomarkers reflecting inflammation (i.e., BMP9, PTX3, and TNFRSF11A), adverse extracellular matrix remodeling (i.e., PGF), congestion (i.e., NT-proBNP and ADM), and myocardial injury (i.e., hsTnT). The gene discussed is NPPB; the disease is rheumatoid arthritis.