In the present study, we established a linear inverse correlation between LVGFI and Log RR for MACEs after adjusting for sex, age, BMI, ischemia cardiomyopathy, LBBB on EKG, QRS duration, RBBB on EKG, intraventricular block on EKG, AF on EKG; Na+, Cl–, BNP, Hb, creatinine, WBC, LV-LGE, RVEDV, and RVEF, respectively (Supplementary Figure 1). The gene discussed is GSTM1; the disease is atrial fibrillation.