Furthermore, abnormalities in the basic lipid profile composition may be compounded by sepsis-triggered lipoprotein modifications, serum level of lipoprotein a [Lp(a)] abnormalities, or apolipoprotein (Apo) B metabolism, contributing to atherosclerosis via different mechanisms than simple changes in composition of lipid profile components (16, 27–30). The gene discussed is LPA; the disease is Sepsis.