Alternatively, defects in DNA repair factors contribute to lymphoma (Knittel et al., 2018), and it is possible that the failure in recruiting RECQ4 to DNA damage sites and facilitating DNA damage repair due to the del (Ala420_Ala463) mutation contributes to lymphomagenesis (Singh et al., 2010; Singh et al., 2012). This evidence concerns the gene RECQL4 and lymphoma.