SENP2 and endothelial dysfunction: Moreover, since SENP2 plays a significant role in the pathomechanism of atherosclerosis by regulating disturbed-flow induced SUMOylation of ERK5 and p53 leading to endothelial dysfunction, SENP2 might serve as potential target combating atherosclerosis as well (Heo et al., 2013; Heo et al., 2015; Heo et al., 2016; Shetty et al., 2020).