Our laboratory also provided molecular proof that the phagocytic Nox2 in lysozyme M (LysM)-positive inflammatory cells (most probably monocytes and macrophages) is responsible for adverse cardiovascular effects of noise since genetic ablation of these LysM-positive cells (by diphtheria toxin treatment of mice with transgenic LysM-specific diphtheria toxin receptor expression) prevented noise-induced vascular oxidative stress, inflammation, endothelial dysfunction and increase in blood pressure (Frenis et al., 2021). The gene discussed is CYBB; the disease is endothelial dysfunction.