Our model also finds increases in leukocyte infiltration into the aortic endothelium, causing endothelial dysfunction (Kroller-Schon et al., 2018) that appears to be phagocytic NADPH oxidase (Nox2) (Kroller-Schon et al., 2018) and macrophage/monocyte-dependent (Frenis et al., 2021). This evidence concerns the gene CYBB and endothelial dysfunction.