CCL5 and cholestasis: In addition, according to the GDA score, the gene most associated with PBC was chemokine C-C motif ligand 5 (Ccl5), and the gene most closely related to the other eight liver diseases was Tnf. From the lateral perspective, we found that tumor necrosis factor (Tnf) was related to all of the nine CLDs, with cirrhosis (GDA score: 0.4) and cholestasis (GDA score: 0.34) showing the closest associations.