TFRC and neoplasm: CircTFRC was reported to be significantly upregulated in 57 cases of BC tissues compared with adjacent normal tissues, and with the increase of tumor stages and grades, its expression level enhanced significantly; miR-107 was proved to be sponged by highly expressed circTFRC, which led to the downstream target gene TFRC release and drive the progression of BC, coincidentally; the target gene TFRC was the ancestral gene of circTFRC (Su et al., 2019).