HOXB13 and posterior cortical atrophy: However, when the expression level of circITCH in PCa is declined, the corresponding sponged miR-17-5p is released, which lead to the downregulated gene expression level of HOXB13 and significantly inhibit the development of PCa (Wang et al., 2019); intriguingly, HOXB13 was proved to be a pivotal upstream regulator of AR-V7 and participate in the development of castration-resistant prostate cancer (CRPC) (Chen Z. et al., 2018; Navarro and Goldstein, 2018).