Furthermore, Galnt2-KO mice showed a reduction of HDL-C and high concentrations of TG, compared to the wild type, probably by regulating three specific targets, the angiopoietin-related protein 3 (ANGPTL3), ApoC-III, and phospholipid transfer protein (Zilmer et al., 2020), ANGPTL3 is considered a promising therapeutic target in patients with dyslipidemia who are at risk of atherosclerotic cardiovascular disease (Lim, 2017). Here, ANGPTL3 is linked to metabolic syndrome.