OGA and cardiomyopathy: Recently, Priya Umapathi et al., using two models of transgenic mice in which OGT and OGA were overexpressed, found a severe development of cardiomyopathy and premature death in the transgenic heart with OGT, whereas in the transgenic heart with OGA, they found a decrease in O-GlcNAcylated proteins and an identical cardiac function to the control model.