SOAT1 and obesity due to melanocortin 4 receptor deficiency: In the same sense, during LGSI, insulin resistance can be generated by the activation of signaling cascades of Janus kinases (JAK) and activating signals of transcription (STAT), which are related to a variety of cytokines, hormones, and growth factors that regulate homeostatic processes including hematopoiesis, stem cell maintenance, growth, development and differentiation in cells of immune lineage (Dodington et al., 2018); however, the chronic activation of JAK/STAT underlies obesity (Sun and Karin, 2012; Kern et al., 2018).