INS and Hyperglycemia: When cells are in an environment abnormally rich in glucose (and insulin), due to chronic hyperglycemia, as is the case of diabetic patients, this situation could be increased, which can lead to a decrease in the efficiency of insulin signaling and, therefore, to insulin resistance at the cellular level and the development of a vicious cycle (glucotoxicity) (Issad et al., 2010; Perez-Cervera et al., 2013), These first observations with respect to the insulin pathway allowed observing the adverse effects of glucose toxicity (Banerjee et al., 2016).