Another example of how O-GlcNAcylation could regulate secreted extracellular matrix proteins as well as cell-surface proteins is by thrombospondin-1 which is a potent proatherogenic and anti-angiogenic protein, and its expression level is enhanced in the plasma and walls of the large blood vessel in a model of hyperglycemia-induced atherosclerosis (Hoffmann et al., 2012); recently, it was demonstrated that thrombospondin-1 is O-GlcNAcylated and regulated by Cr3+ promoting atheroprotective effects (Ganguly et al., 2017). Here, THBS1 is linked to Hyperglycemia.