Treatment-related adverse events, as graded by Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0, included rash (14.8%), fever (16.4%), fatigue (26.2%), hypothyroidism (18%), hypertension (50.8%), elevated ALT/AST/ALP levels (41.0%), vitamin D deficiency (37.7%), hyperlipidemia (34.4%), anemia (23.0%), and dental ulcer (2/61, 3.3%). The gene discussed is GPT; the disease is hypertensive disorder.