LGALS1 and cancer: Moreover, Integrin β1 could associate with the carbohydrate-recognizing domain (CRD) of Galectin-1 (Gal-1) secreted by activated cancer-associated fibroblasts (CAFs) via its extracellular carbohydrate structure, resulting in Gli1 expression which may further activating Wnt/β-catenin signaling, and finally trigger the EMT process in GC cells (Elola et al., 2005; Chong et al., 2016; Zhang et al., 2020).