In addition to integrin α5β1, the integrin αvβ5 could be activated by autocrine TGF β-induced in CRC cells, enhancing integrin αvβ5/Src signaling and then inducing the dissociation of VE-cadherin junctions between endothelium cells which facilitated extravasation (Ma et al., 2008). This evidence concerns the gene SRC and colorectal carcinoma.