TMEM268 and neoplasm: In GC cells lacking transmembrane protein 268 (TMEM268), a novel protein involved in tumorigenesis, lead to increased ubiquitin-mediated degradation of integrin β4 and cytoskeleton remodeling, thus losing the possibility of circulating tumor cells (CTCs) adhere to vascular endothelium, extravasate into other organs, and eventually fail to form metastatic colonization (Hong et al., 2019).