Substantial evidence showed that altered expression of integrins correlated with GC metastasis, and dysregulated integrin-mediated signaling pathways, such as focal adhesion kinase (FAK)/p21-activated kinase (PAK), Wnt/β-catenin and FAK/glycogen synthase kinase-3β (GSK3β), played essential roles in EMT process. The gene discussed is PTK2; the disease is gastric cancer.