In many types of cancers, increased angiopoietin 2 (Ang2) accompanied by the decreased angiopoietin receptor Tie2 exhibit the predisposition to the integrin α5β1-Ang2 interaction, which has been implicated in compromised permeability through integrin β1 signaling (Imanishi et al., 2007; Hakanpaa et al., 2015). The gene discussed is ANGPT2; the disease is cancer.