RelB and nuclear receptor subfamily 4 group A member 1 (NR4A1)/p300/Sp increase β1 transcriptional activity in CRC Hedrick et al. (2017), Zhou et al. (2018). Forkhead box O3 (FOXO3a) increases β1 transcriptional activity in GC Hu et al. (2017). The gene discussed is EP300; the disease is colorectal carcinoma.