Guha et al. found that integrin α2β1/α5β1 could colocalize with EGFR on cell surface in the anoikis-resistant CRC cells which was involved in the migration of CRC cells from the primary site to newly distant site(s) and could grant the cells with stem cell-like properties; the integrin α2β1/α5β1-EGFR complex can activate the ERK/AKT-mediated survival pathway and inhibit caspase-3 activation and consequently inducing anoikis resistance in the absence of ECM (Guha et al., 2019). This evidence concerns the gene AKT1 and colorectal carcinoma.