Obviously, SMOC1 expression was significantly downregulated in bladder urothelial carcinoma, breast invasive carcinoma (BRCA), cholangiocarcinoma, kidney renal clear cell carcinoma, kidney renal papillary cell carcinoma, liver hepatocellular carcinoma, prostate adenocarcinoma, thyroid carcinoma, and uterine corpus endometrial carcinoma, whereas the expression of SMOC1 was increased in kidney chromophobe and LUAD. The gene discussed is SMOC1; the disease is uterine corpus endometrial carcinoma.