Consist with GEPIA2 analysis, a significant positive correlation was found between SMOC1 expression and better prognosis of all World Health Organization (WHO) grade I (p < 0.0001), WHO grade II (p = 0.024), and WHO grade III (p = 0.003) glioma, but no correlation was observed between the expression of SMOC1 and WHO grade IV glioma (p = 0.094) (Figure 2E). Here, SMOC1 is linked to central nervous system cancer.