In high-grade glioma, SMOC1 was significantly positively correlated with stemness (correlation = 0.42, p < 0.001) and negatively associated with hypoxia (correlation = -0.39, p < 0.001), EMT (correlation = -0.38, p < 0.001), and metastasis (correlation = -0.32, p < 0.001) (Figure 5B). The gene discussed is SMOC1; the disease is central nervous system cancer.