CD4 and neoplasm: The expression of SMOC1 was significantly negatively correlated with levels of infiltrating B cells (cor = −0.263, p = 5.13e-09), CD8+ T cells (cor = −0.355, p = 1.31e-15), CD4+ T cells (cor = −0.108, p = 1.81e-02), macrophages (cor = −0.212, p = 3.47e-06), neutrophils (cor = -336, p = 5.69e-14), and dendritic cells (cor = −0.296, p = 4.26e-11) in LGG tumor microenvironment (Figure 6A).