Single-SNP MR analyses showed that SNPs rs1800562 (HFE) and rs855791 (TMPRSS6) were associated with a significant effect of serum iron or transferrin saturation on sepsis, while SNPs rs1800562 (HFE) and rs2413450 (TMPRSS6) were significantly related to the causal effect of ferritin on sepsis (Figure 2). Here, TMPRSS6 is linked to Sepsis.