GWAS summary-level datasets were downloaded from IEU OpenGWAS Project (https://gwas.mrcieu.ac.uk/), including serum iron (GWAS ID: ieu-a-1049), transferrin (GWAS ID: ieu-a-1052), transferrin saturation (GWAS ID: ieu-a-1051), ferritin (GWAS ID: ieu-a-1050), hemoglobin (GWAS ID: ebi-a-GCST004615), erythrocytes count (GWAS ID: ebi-a-GCST004601), reticulocytes count (GWAS ID: ebi-a-GCST004622), and sepsis (GWAS ID: ieu-b-69). The gene discussed is TF; the disease is Sepsis.