Mice lacking the gene for SOD1 are considered an animal model to study hepatocellular carcinoma development following NASH, as they spontaneously present in their hepatocytes high oxidative stress, impaired very-low-density lipoprotein (VLDL) secretion that leads to lipid accumulation, necroptosis and inflammation (49). This evidence concerns the gene SOD1 and metabolic dysfunction-associated steatohepatitis.