SELENOS and Hypercholesterolemia: Selective loss of housekeeping selenoproteins, such as DIO1, SELENOP, TXNRD1, and SELENOF, led to upregulation of genes involved in cholesterol biosynthesis, and downregulation of genes involved in cholesterol metabolism and transport, suggesting an overall effect of this subset of selenoproteins in hepatic lipoprotein metabolism that favours hypercholesterolaemia (42).