LIGHT (tumor necrosis factor superfamily member 14, TNFSF14) expression in activated CD8+ T cells induced by feeding a choline-deficient high-fat diet (CD-HFD) promoted NASH and HCC progression in mice via interacting with lymphotoxin-β receptor (LTβR) in hepatocytes (23). Here, LTBR is linked to metabolic dysfunction-associated steatohepatitis.