The subgroup analysis categorized based on eGFR < 60 ml/min/1.73 m2, proteinuria > 1 g/d, albumin < 30 g/l, anemia, uric acid, and TG suggested that patients both presenting with AS and eGFR < 60 ml/min/1.73 m2 had a significant trend for a shorter time to reach end point than other subgroups. The gene discussed is ALB; the disease is anemia.