We studied plasma concentrations of CCL2, CCL3, CCL4, and CCL5 [also referred to as macrophage chemo-attractant protein-1 (MCP-1), macrophage inflammatory protein-1 alpha (MIP1α), macrophage inflammatory protein-1 beta (MIPβ), and RANTES, respectively] in patients with iAMD to improve our understanding of the systemic inflammatory milieu that exists in patients who are at-risk to develop AMD. Here, CCL5 is linked to age-related macular degeneration.