Four proteins including Intercellular adhesion molecule-1 (ICAM1), CC chemokine ligand 18 (CCL18), Dipeptidyl-peptidase 4 (DPP4), Vascular endothelial growth factor D (VEGFD), were found correlate to arthritis activity evaluated by swollen joint count (SJC), among which ICAM-1 and CCL18 were reported relevant to synovial tissue in rheumatoid arthritis activity. Here, ICAM1 is linked to rheumatoid arthritis.