We identified TLR3, PTGER3, and IKZF1 as susceptibility genes for SJS/TEN with SOC, demonstrated that they are able to regulate mucocutaneous inflammation, including ocular surface inflammation, and reported functional interactions between TLR3 and PTGER3, or TLR3 and IKZF1. Here, TLR3 is linked to Schwartz-Jampel syndrome.