We identified TLR3, PTGER3, and IKZF1 as susceptibility genes for SJS/TEN with SOC, demonstrated that they are able to regulate mucocutaneous inflammation, including ocular surface inflammation, and reported functional interactions between TLR3 and PTGER3, or TLR3 and IKZF1. The gene discussed is PTGER3; the disease is Schwartz-Jampel syndrome.