Using human samples, we found that EP3 protein levels were much lower in the conjunctival epithelium of patients with SJS/TEN with SOC than in our control subjects (27), and that IP-10, which is greatly induced by the TLR3 ligand on the ocular surface epithelium, was significantly downregulated in the tears of patients with SJS/TEN in the chronic stage (34). Here, PTGER3 is linked to toxic epidermal necrolysis.