For example, MMP-9 and CG can degrade the extracellular matrix to prepare for tumor metastasis (Wilson et al., 2010; Park et al., 2016; Cabel et al., 2017); 2) NETs capture circulating tumors cells (CTCs), cells that are shed from the primary tumor site or metastasis, entering the vasculature, and thus escape from immune attack. The gene discussed is MMP9; the disease is neoplasm.