Various components in NETs, such as: MMP-9 (Cools-Lartigue et al., 2013; Boone et al., 2015), CG (Cabel et al., 2017), and NE (Cools-Lartigue et al., 2013), can induce the expression of vascular endothelial growth factor (VEGF) to promote tumor growth, metastasis and angiogenesis. The gene discussed is MMP9; the disease is neoplasm.