miR-100 inhibits the expression of mTOR by directly targeting its 3′-UTR and acts as a tumor suppressor in esophageal squamous cell carcinoma (ESCC) (Sun et al., 2013; Zhang N. et al., 2014) and bladder cancer (Xu et al., 2013). The gene discussed is MTOR; the disease is esophageal squamous cell carcinoma.