The activation of β-catenin in hepatocytes can change the liver microenvironment and lead to the specific targeting of iNKT cells. The activation of β-catenin in hepatocytes triggers the pro-inflammatory process related to the activation of NF- κ B. In the process of liver inflammation induced by β-catenin, iNKT cells showed anti-inflammatory properties. In HCC induced by β-catenin, iNKTs and LECT2 are the key cellular and molecular effectors to control tumor progression. This evidence concerns the gene LECT2 and neoplasm.