CCR2 antagonists inhibited the infiltration of TAM and MDSC and delayed tumor growth in tumors of mice expressing A3b and A3b. Mechanically, upregulation of A3B in HCC inhibs the global abundance of H3K27me3 and reduces the presence of H3K27me3 on the chemokine Ccl2 promoter by interacting with the multicomb repressor complex 2(PRC2), thus recruiting large amounts of TAM and MDSC. This evidence concerns the gene CCR2 and hepatocellular carcinoma.