CBL and cancer: LNC-EGFR specifically binds to EGFR and prevents its interaction with c-CBL and is ubiquitinated by c-CBL, which stabilizes and enhances the activation of its own and its downstream AP-1/NF-AT1 axis, thus causing EGFR expression. LNC-EGFR has been associated with immunosuppressive status and cancer by promoting Treg cell differentiation.