Liver-specific MYC transgenic mice fed the MCD diet were induced. Blockage of CPT with the pharmacological inhibitor perhexiline reduced apoptosis of CD4+T cells in the liver and inhibited tumor formation in HCC. These results provide useful information for the potential targeting of the CPT family to salvage intrahepatic CD4+T cells and for immunotherapy to assist NAFLD-promoted HCC. Here, CD4 is linked to hepatocellular carcinoma.