CD274 and hepatocellular carcinoma: Treg-induced inhibition of IFN-γ secretion is partially prevented by neutralizing PD-1 and PD-L1 antibodies in HCC patients. In HCC, peripheral blood Tregs upregulate checkpoint inhibitors and promote systemic immune dysfunction and antitumor activity through several inhibitory pathways, presumably contributing to the development of tumors at a young age.