MicroRNA (miR-17-92) clusters from the extracellular vesicles (EVs) of M2-polarized tumor-associated macrophages (M2-TAMs) stimulate the imbalance of the TGF-β1/BMP-7 pathway, TGF-β1/BMP-7 pathway imbalance significantly promotes HCC cell invasion and stem cells by increasing the expression of differentiation inhibitor 1(ID1). This evidence concerns the gene TGFB1 and neoplasm.