The heterozygous loss of SPTBN1 significantly upregulated the liver expressions of IL-1α, IL-1β and IL-6, and increased the proportion of myeloid inhibitory cells (MDSC) and CD4CD25Foxp3 regulatory T cells (Foxp3Treg) in liver, which promoted the occurrence of HCC in DDC-fed mice. The gene discussed is SPTBN1; the disease is hepatocellular carcinoma.