Chang et al. 's study confirmed that NanoMnSor improves the effectiveness of anti-PD-1 antibodies and whole-cell cancer vaccine immunotherapy by encouraging macrophage polarization to an immunostimulating M1 phenotype, decreasing hypoxica-induced tumor infiltration of tumor-associated macrophages, and raising the number of CD8 cytotoxic T cells in tumors, thereby reprogramming immunosuppressive TME (Chang et al., 2020). This evidence concerns the gene CD8A and cancer.