Stress granules contain high amounts of RNA, including transfer-RNA (t-RNA) (Kedersha et al., 2002) and mis-processing of RNA-binding proteins such as FUS and stress granules has been shown to be pathogenic in ALS suggesting (Zhang et al., 2020) that DNMT2-mediated t-RNA modification plays a role in the cellular stress response (Bohnsack et al., 2019). The gene discussed is TRDMT1; the disease is amyotrophic lateral sclerosis.