Global DNA methylation in fALS cellular models revealed an increase in 5-mC in cells transduced by mutant SOD1, but no significant alterations were observed in cells transduced by wild type (WT) or pathological mutant FUS or TDP-43 indicating that different ALS-causing genes contribute to global epigenome alteration in distinct ways (Masala et al., 2018). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.