Accordingly, as we show perceived proximity of 5-mC with cytoplasmic FUS aggregates, we hypothesize that 5-mC contributes to the pathological FUS recruitment and stress granule aggregation in ALS, whereas arginine methylation contributes to pathological mislocation (Naumann et al., 2018) presuming synergistic impact. This evidence concerns the gene FUS and amyotrophic lateral sclerosis.