KCTD1 and cancer: Among the top ranked oncogenes, ABL1_BCR ranked first with connections to 28 drugs, followed by BCR_ABL1 and KRAS with 20 and 12 drugs (Figure 2D), implying that the highly drug-connected genes that are not currently identified as cancer genes could actually be causally implicated in cancer therapy, such as KCTD1_PCAT18 fusion, TNFRSF9, LTB, and NFATC4, which showed connections to over 18 drugs and ranked as the top five genes (Supplementary Figure S2).