For example, one study based on a large-scale genomic analysis revealed that lung squamous, head and neck, and a subset of bladder cancers shared highly concordant signatures typified by TP53 alterations, TP63 amplifications, and high expression of immune and proliferation pathway genes, implicating that those different cancers perhaps require similar treatment approaches (Hoadley et al., 2014). Here, TP53 is linked to cancer.