FAS and Sepsis: TLR3 was observed to play a deleterious role in mediating cardiac dysfunction in sepsis by increasing cecal ligation and puncture-induced cardiomyocyte apoptosis as well as Fas and Fas ligand expression in the myocardium (Gao et al., 2012; Kalbitz et al., 2016; Fattahi et al., 2017).