YTHDF1 and Sepsis: The depletion of YTHDF1 alleviated the immune response to bacterial infection as evidenced through an observation that YTHDF1 knockdown macrophages improved the immune paralysis of macrophages, Th1/Th17 cells, and cytotoxic T lymphocytes and reduced the entry of macrophages into the brain to cause endothelial damage in severe sepsis rats with ECMO (Xing et al., 2021).