It is worthy of note, compared with samples at first diagnosis, the detrimental factors of USP30-AS1, AC114271.2, AF064858.8 and RP11–22L13.1 were upregulated, and the protective factors of MIR181A1HG, RP11–544A12.4 and MIR133A1HG exhibited a decreased tendency in first relapsed AML patients (Figure 7). The gene discussed is MIR181A1HG; the disease is acute myeloid leukemia.