Subsequently, we focused on the effect of WTAP interference on HSCs in LF and found that interfering with WTAP promoted the proliferation of HSCs and increased the expression of α-SMA, a marker of HSC activation and collagen I, the main component of extracellular matrix, which indicated that interfering with WTAP could promote the occurrence and development of LF. Here, ACTA1 is linked to Lassa fever.