Wang Y. et al. (2021) found that ApoA4 may reduce LF and liver injury by inhibiting LF mediators and inflammatory cytokines and suppressing proinflammatory hepatic M1 cell invasion. Although some genes have not been proven to be related to LF, they are involved in fibrosis in other tissues. For example, Ninj1 has been shown to promote the activation of macrophages by enhancing the interaction with epithelial cells, thus enhancing the inflammatory response of macrophages to participate in the occurrence and development of pulmonary fibrosis (Choi et al., 2018). This evidence concerns the gene APOA4 and Lassa fever.