TUBB4A and leukodystrophy: Furthermore, it is well-established that mutations in TUBB4A are linked to hypomyelinating leukodystrophies, consistent with an important role for TUBB4A in oligodendrocyte function and the myelination of axons during postnatal brain development (Figure 5; Hersheson et al., 2013; Lohmann et al., 2013; Simons et al., 2013; Hamilton et al., 2014; Miyatake et al., 2014; Purnell et al., 2014; Lu et al., 2017).