Based on the above results, we summarized the characteristics of HCC patients with a poor prognosis: microenvironment immunosuppression, TP53 mutation, genomic instability (high TMB), stronger characteristics of CSCs (high mRNAsi), inactive metabolism, vascular invasion, advanced stage (TNM III-IV, BCLC B-C, and CLIP > 2), main tumor size > 5 cm, poor differentiation, and cirrhosis. Here, TP53 is linked to Cirrhosis.