Circ-SHPRH encodes a 17 kDa peptide with a length of 146 amino acids, named SHPRH-146aa, which could protect its parental gene SNF2 histone linker PHD RING helicase (SHPRH) from degradation via the ubiquitin proteasome and functions as an inhibitor of glioblastoma (Zhang et al., 2018a). Here, SHPRH is linked to glioblastoma.