One of them—rno-miR-344a-2—was previously associated with aging and regulation of a-SMA (Wang et al., 2015) and the other—rno-miR-208a-3p—mediates the myocardial endoglin expression that led to increased myocardial fibrosis (Wang et al., 2014). This evidence concerns the gene ENG and Myocardial fibrosis.