Intranuclear actin-cofilin rods were identified as hallmarks in muscle cells of patients with intranuclear rod myopathy (IRM), a specific form of nemaline myopathy (Goebel and Warlo, 1997; Sparrow et al., 2003; Ilkovski et al., 2004; Domazetovska et al., 2007a; Domazetovska et al., 2007), and Huntington’s disease (HD) (Munsie et al., 2011). Here, CFL1 is linked to nemaline myopathy.