Although several studies have evaluated the function of FBXW7 in ubiquitin degradation (Yeh et al., 2018; Yumimoto and Nakayama 2020), to knowledge, this is the first study the mechanism by which FBXW7 participates indegrading VDAC3 in ALL. The gene discussed is FBXW7; the disease is acute lymphoblastic leukemia.