BMP2 and neoplasm: More research has reported that BMPs, especially a supra-physiological dose of BMP-2, induces tumorigenesis, not tumor suppression (Figure 4; Jin et al., 2001; Kang et al., 2011; Wu J. B. et al., 2011; Nishimori et al., 2012; Tian et al., 2017; Zhang et al., 2018).