After continued clinical use, the adverse effects of BMP-2 (e.g., inflammatory, ectopic bone formation, infection, and potential tumorigenicity) have come into focus; the high dose and off-label application of BMP-2 have also aroused concern (Cahill et al., 2009; Tian et al., 2017; Pardali et al., 2018; Hashimoto et al., 2020; Hsu et al., 2020). The gene discussed is BMP2; the disease is infection.