Similar to intrinsic ROS effects, H2O2 treatment induced cellular senescence and apoptosis in HF-MSCs, which was accompanied by ROS accumulation and upregulated expression of proteins related to cellular senescence (P53, P16, and P21), apoptosis (57 kDa AIF, cleaved caspase 3, and Cyt C), and DNA damage and repair (γH2AX, Rad 51, Ku70, Ku80, PAR, and 116 kDa PARP1). Here, TP53 is linked to hydrops fetalis.