To clarify DNA damage alleviation or DNA repair, which affect the attenuation of cellular senescence and apoptosis of HF-MSCs, we generated PARP1-, PBX1-, and PARP1 + PBX1-overexpressing HF-MSCs (Figure 4) and compared the effects of PBX1-overexpression, PARP1-overexpression, and PARP1 + PBX1-overexpression on HF-MSC ROS activation, cellular senescence, and apoptosis. The gene discussed is PARP1; the disease is hydrops fetalis.