In contrast, PBX1 overexpression reduced cellular senescence and apoptosis in H2O2-treated or -untreated HF-MSCs, which was accompanied by decreased ROS levels and down-regulated expression of proteins related to cellular senescence (P21, P16, and P53), apoptosis (57 and 67 kDa AIF, Cyt C and cleaved caspase 3), and DNA damage and repair (γH2AX, Rad 51, Ku70, Ku80, PAR and 89 and 116 kDa PARP1). This evidence concerns the gene AIFM1 and hydrops fetalis.