Combined inhibition of Checkpoint kinase 1 (Chk1), a key regulator of cell cycle transition in response to DNA damage, and G9a with BRD4770 disrupted pancreatic cancer cell growth, replication fork progression, and DNA damage signaling, ultimately leading to induction of cell death (Urrutia et al., 2020). Here, CHEK1 is linked to familial pancreatic carcinoma.