According to our results, ZBTB32 and CENPS were regarded as protective elements for OS, while PALB2 and BRCA2 acted as risk factors for RFS in CC, but these results were not all in agreement with previous studies in carcinoma, perhaps due to different molecular mechanisms and different genetic mutations in patients (Krona et al., 2004; Breast Cancer Association et al., 2021; Padella et al., 2021; Satyananda et al., 2021). This evidence concerns the gene PALB2 and cholangiocarcinoma.