Consequently, administering a cholesterol depletor, hydroxy-propyl-β-cyclodextrin (HPβCD), resulted in disruption of lipid raft integrity, and abrogated LDL-mediated AKT phosphorylation in the SK-45 RCC cell line as well as the patient-derived PNX0010 ccRCC cell line (Naito et al., 2017). Here, AKT1 is linked to nonpapillary renal cell carcinoma.