According to AJCC TNM staging, the mRNA expression level of FAM83D was enhanced in STAD as the stage of the tumor progressed, and stage III (169 samples) and IV (41 samples) showed the highest expression in STAD, while FAM83E, FAM83F, FAM83G, and FAM83H had significant down-regulation in their expression level with the malignant progression of tumors, and had the lowest expression level in stage IV (41 samples) STADs (Figure 4). The gene discussed is SACK1E; the disease is neoplasm.