According to these studies, FAM83C and FAM83E are up-regulated in bladder and ovarian cancers (Cipriano et al., 2014; Snijders et al., 2017), and FAM83A, FAM83C, FAM83D, and FAM83E have been shown to promote the transformation of human breast epithelial cells (Cipriano et al., 2014). The gene discussed is SACK1E; the disease is ovarian carcinoma.