SACK1D and ovarian carcinoma: According to these studies, FAM83C and FAM83E are up-regulated in bladder and ovarian cancers (Cipriano et al., 2014; Snijders et al., 2017), and FAM83A, FAM83C, FAM83D, and FAM83E have been shown to promote the transformation of human breast epithelial cells (Cipriano et al., 2014).