One of the potential reasons for these discordances could be due to the involvement of other dominant immunoregulatory molecules that play along with PD-L1/PD1 pathway in HCC microenvironment (Lafleur et al., 2018; Heinrich et al., 2020; Sharma and Motedayen Aval, 2021). Here, CD274 is linked to hepatocellular carcinoma.