Chamoto et al. reported that tumor-reactive T cells boosted by PD-L1 blockade possessed activated mitochondria with augmented ROS production, and improving ROS generation using ROS precursors or mitochondrial uncouplers synergized the antitumor activity of PD-1 blockade by expansion of effector/memory cytotoxic T cells in draining lymph nodes (Chamoto et al., 2017). Here, CD274 is linked to neoplasm.