Besides, the study of the possible influences of CXCR4 and CXCR7 on breast cancer activities has also revealed that ablation of the CXCR4 or CXCR7 gene considerably condensed tumor cell expansion, migration, and invasion and prolong the conversion of the G1/S cycle (Yang et al., 2019). This evidence concerns the gene ACKR3 and neoplasm.