Moreover, CRISPR/Cas9-mediated ablation of the checkpoint kinase WEE1(106), V-set pre-B-cell surrogate light chain 1 (VPREB1) (Khaled et al., 2021), Abl interactor 1 (Abi1) (Faulkner et al., 2020), baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5) (Narimani et al., 2019), and histone deacetylase 1 and 2 (HDAC1/2) supports desired anti-cancer outcomes in HCC (Liang et al., 2020), multiple myeloma (MM) (Khaled et al., 2021), BCR-ABL-induced leukemia (Faulkner et al., 2020), acute myeloid leukemia (AML) (Narimani et al., 2019), and chronic myeloid leukemia (CML), respectively. This evidence concerns the gene WEE1 and chronic myelogenous leukemia, BCR-ABL1 positive.