CatG and NE along with neutrophil-derived externalized nucleosomes (which form NETs) have been identified to stimulate coagulation via destruction and inactivation by proteolysis of the tissue factor pathway inhibitor (TFPI), which is an endogenous anticoagulant, resulting in arterial thrombosis (Massberg et al., 2010). The gene discussed is TFPI; the disease is Arterial thrombosis.