This phenomenon was validated by an additional study demonstrating an increase of protein turnover by CatG incubated with an excess of LF, and found that high serum levels of LF and CatG activity in osteomyelitis patients embody CatG polymorphism, characterized by the exchange of asparagine to serine at position 125 (N125S) (Thorpe et al., 2018). This evidence concerns the gene CTSG and osteomyelitis.