FAP and neoplasm: These nanocomplexes were validated to be able to accumulate at tumor regions and release HSA-PTX triggered by FAP-α that specifically expresses on cancer-associated fibroblasts (CAFs), then the release of small-sized HSA-PTX was enhanced for deep tumor penetration and tumor killing through the produced hyperthermia upon near-infrared (NIR) laser irradiation, suggesting that the encapsulation of small-sized HSA-PTX into thermosensitive liposomes can overcome the disadvantages of small nanoparticles including short circulation time and poor tumor accumulation.