The novel bovine serum albumin (BSA)-based nanocomplexes encapsulated with both Bcl-2-specific small interfering RNA (siRNA) and gold (Au) nanorods were developed (Figure 2C), and the downregulation efficacy of siRNA on Bcl-2 antiapoptotic protein expression as well as the photothermal property of nanocomplexes were further estimated with the aim of providing an efficient approach for targeted breast cancer treatment (Choi et al., 2015). The gene discussed is BCL2; the disease is breast cancer.