Although the described multicomponent albumin nanocomplexes have a relatively larger size than the clinical used diameter (about <200 nm), their biocompatibility and synergistic antitumor effects prevail over the previous lipid-based and polymer-based nanocomplexes, which show a great potential for the further application in synergistic cancer gene and photothermal therapy in vivo (Choi et al., 2015). The gene discussed is ALB; the disease is cancer.