Clinical presentation of neuroblastoma varies widely, ranging from asymptomatic patients to symptoms related to local compression of adjacent structures and to catecholamines or vasoactive intestinal peptide (VIP) secretion, such as hypertension and intractable diarrhea, systemic non-specific symptoms, such as fever and weight loss, or cytopenia related to bone marrow metastases (5, 6). This evidence concerns the gene VIP and Hypertension.