AKT1 and cancer: Targets of common downregulated miRNAs mainly were Axon guidance (hsa04360, P = 2.14e−5), proteoglycans in cancer (hsa05205, P = 3.91e−5), pathways in cancer (hsa05200, P = 4.64e−5), FoxO signaling pathway (hsa04068, P = 8.40e−5), and PI3K-Akt signaling pathway (hsa04151, P = 1.94e−5) (Figure 7B and Supplementary Table 5).