CD40LG and tuberculosis: For example, the lower the level of anti-LAM or AM antibodies in patients with TB, the faster the progress of TB and the higher the frequency of dissemination (Costello et al., 1992); human anti-HBHA IgM antibodies could prevent Mtb from entering the epithelial cells of patients with TB (Shin et al., 2006); anti-Ag85A IgG could reduce the risk of active TB, reduce cavities, and remove sputum bacteria (Liang et al., 2018).