CD4 and tuberculosis: In addition, a meta-analysis showed that rhuIL-2 immunoadjuvant therapy was safe for patients with PTB/MDR-TB, and could promote the proliferation and transformation of CD4+ T cells and NK cells, improving the sputum bacterium-negative rate of patients with TB, however, there was no significant improvement in radiographic changes in patients with TB (Zhang et al., 2018).