The RANKL/OPG ratio is associated with the degree of bone destruction in periodontitis (Bostanci et al., 2007), and an increased RANKL/OPG ratio may serve as a biomarker for the occurrence of periodontitis (Belibasakis and Bostanci, 2012; Tsukasaki, 2021). This evidence concerns the gene TNFRSF11B and periodontitis.